1,2,3-triazolyl amino acids as AMPA receptor ligands

N J Stanley; D Sejer Pedersen; B Nielsen; T Kvist; J M Mathiesen; H Bräuner-Osborne; D K Taylor; A D Abell

doi:10.1016/j.bmcl.2010.09.139

1,2,3-triazolyl amino acids as AMPA receptor ligands

Bioorg Med Chem Lett. 2010 Dec 15;20(24):7512-5. doi: 10.1016/j.bmcl.2010.09.139. Epub 2010 Oct 14.

Authors

N J Stanley¹, D Sejer Pedersen, B Nielsen, T Kvist, J M Mathiesen, H Bräuner-Osborne, D K Taylor, A D Abell

Affiliation

¹ Discipline of Chemistry, The University of Adelaide, Adelaide, Australia.

PMID: 21036612
DOI: 10.1016/j.bmcl.2010.09.139

Abstract

The central nervous system glutamate receptors are an important target for drug discovery. Herein we report initial investigations into the synthesis and glutamate receptor activity of 1,2,3-triazolyl amino acids. Two compounds were found to be selective AMPA receptor ligands, which warrant further investigation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acids / chemical synthesis
Amino Acids / chemistry*
Amino Acids / pharmacology
Binding Sites
Catalysis
Computer Simulation
Copper / chemistry
Ligands
Receptors, AMPA / antagonists & inhibitors*
Receptors, AMPA / metabolism
Ruthenium / chemistry
Triazoles / chemistry*

Substances

Amino Acids
Ligands
Receptors, AMPA
Triazoles
Copper
Ruthenium